5. Game 6, 2012 Eastern Conference Finals
The Heat were facing elimination in Boston after losing three straight to the star-studded Celtics. LeBron put the Heat on his back, scoring 45 points on 19-of-26 shooting, ripping down 15 rebounds, and handing out 5 assists as Miami won by 19 to force a Game 7 back at home. The Heat, of course, won that game, too, and went on to win the NBA title, the first with LeBron.